Zepbound®

Zepbound is a drug with the active ingredient Tirzepatide used in the treatment of weight management. It works by lowering blood sugar levels,supporting the body’s natural production of insulin, regulating appetite and stimulating fat burning. The drug has been approved by the FDA in America, but will not enter the Dutch market.

Tirzepatide, the active ingredient in Zepbound, is an incretin mimetic that mimics the action of 2 different incretin hormones. These hormones have different effects: they lower fasting glucose levels and they stimulate the release of insulin after meals, which helps regulate blood sugar levels. Furthermore, it slows gastric emptying, acts on appetite in the brain and stimulates fat burning, which contributes to weight loss.

Zepbound can be obtained in the U.S. only with a doctor’s prescription. It is not available on the Dutch market and will not become so, according to manufacturer Eli Lilly.

Zepbound is appropriate in the US for obese adults, BMI ≥ 30 or overweight adults, BMI ≥ 27, with at least one weight-related condition. It is not suitable for children.

Zepbound is not available on the Dutch market.

Zepbound works in two ways: it stimulates insulin production when blood sugar levels are high and reduces appetite at the same time. This not only improves blood sugar regulation, but also supports weight loss and fat burning.

• The active ingredient in Zepbound is Tirzepatide.
• The other substances in this medication are sodium chloride, dibasic sodium phosphate heptahydrate and water for injection.

Zepbound is approved by the FDA, making it labeled safe for private use in the US.

Zepbound and Mounjaro both contain the substance Tirzepatide and are both produced by manufacturer Eli Lilly. However, Zepbound is registered as a treatment for obese and overweight people with weight-related conditions. Mounjaro, on the other hand, is registered for the treatment of type II diabetes in addition to treatment for obesity. Dosage
Mounjaro is currently available on the Dutch market and Zepbound is only available on the U.S. market.

As with other weight management medications, side effects can occur with Zepbound:

• Nausea;
• Upset stomach;
• Diarrhea;
• Constipation;
• Fatigue.

These side effects usually disappear after a few days or weeks.

If you have questions about side effects or get (too many) side effects, contact your doctor, pharmacist or coach. You can also report side effects directly through the Nederlands Bijwerkingen Centrum Lareb, website www.lareb.nl. By reporting side effects, you can help us learn more about the safety of this medicine. A complete list of side effects can be found in the package insert.

Zepbound is administered as a subcutaneous injection, that is, subcutaneous injection. Do not inject the drug into a vein or muscle.

• In the thigh;
• In the belly;
• In the upper arm.