What is Mounjaro
Mounjaro is a medication containing the active substance tirzepatide. It is used for two medical applications:
- Weight loss and weight maintenance in adults with obesity (BMI ≥ 30) or overweight (BMI 27–30) with weight-related health problems, such as high blood pressure, sleep apnea, or high cholesterol.
- Treatment of type 2 diabetes in adults, when diet and exercise alone are not sufficient to lower blood sugar.
At The Body Clinic, a doctor assesses during the consultation whether medication treatment is suitable within a medical weight management program. More information about our medical approach can be found in our treatment program.
Instructions for Mounjaro Use
Below you will find brief usage information for the pen. Always read the package leaflet or ask your doctor/pharmacist for an explanation.
Important information about the pen
- Each pen contains one fixed dose.
- You can inject 4 times with one pen (once a week).
- After 4 injections, the pen automatically locks.
- There will always be some residual fluid left; this is not a full dose.
Check before each injection
- Place a new needle on the pen.
- Turn the back 2 clicks until the first line appears in the window.
- Press the back until a '0' reappears on the screen.
- If a drop appears on the needle, the pen is ready for use.
- If you do not see a drop, repeat the steps; if this persists after 2 attempts, replace the needle and repeat the check.
- If a drop appears, turn the pen completely until '1' is displayed on the screen and administer the dose.
Storage
- In the refrigerator (2–8 °C), do not freeze and protect from light.
- After opening: up to 30 days at room temperature (max. 30 °C) possible.
Tirzepatide
Tirzepatide is the active substance in Mounjaro and is produced by Eli Lilly. It is an incretin mimetic: it activates both the GIP and GLP-1 receptors. These receptors play a role in the release of insulin after meals, reducing glucagon secretion, and influencing appetite and satiety. Through this combined action, tirzepatide helps to regulate blood sugar and supports weight loss and weight maintenance for the appropriate indications.
Mounjaro for Weight Loss
Mounjaro contains tirzepatide, a substance that acts like two natural hormones in your body: GIP and GLP-1. These hormones are produced in the intestines after a meal and help the body properly utilize sugar from food. Under their influence, the pancreas produces more insulin when blood sugar rises, and the liver releases less sugar into the blood.
Summarized action:
- lowering blood sugar levels when they are too high;
- slowing down gastric emptying, so food remains in the stomach longer;
- providing a feeling of satiety, causing you to eat less; and thus supporting weight loss and weight maintenance in obesity or overweight.
The effect gradually builds up during treatment. Mounjaro only lowers blood sugar when it is too high.
Results after 12 months (SURPASS-3)
The table below shows the average weight change and the percentage of participants who achieved at least 5%, 10%, or more than 15% weight loss after 52 weeks of Mounjaro treatment, alongside diet and exercise.
| Dosage per week | Average weight loss | ≥ 5% weight loss | ≥ 10% weight loss | > 15% weight loss |
|---|---|---|---|---|
| 5 mg | −7,5 kg | 81% | 55% | 34% |
| 10 mg | −10,7 kg | 89% | 73% | 50% |
| 15 mg | −12,9 kg | 91% | 80% | 57% |
| Comparison group | +2,3 kg | 26% | 8% | 3% |
